GUT-BIOME MODULATION WITH HUMAN MILK OLIGOSACCHARIDE (HMO) BASED SYNBIOTIC FOR A COMPLETE AND DEEP REMISSION IN CROHN’S DISEASE: A CASE STUDY

Abstract BACKGROUND Gut microbiome plays a crucial role in modulation of inflammatory and immune pathways. Diverse bacterial species from gut microbiota feed on specific prebiotics (non-digestible dietary fibers) producing metabolites, such as short chain fatty acids (SCFA). These metabolites beneficially affect the intestinal mucosa with their metabolic immunologic homeostasis, barrier integrity. Recently gut-biome use gained interest potential targets for therapeutic development, instance Inflammatory Bowel Disease (IBD) which includes Crohn’s disease (CD) ulcerative colitis (UC). HYPOTHESIS Nourishing thru synbiotic formulation can enhance interspecies synergy production improved integrity more naturally. This is superior holistic approach to reduce gut-inflammation. METHODS (CLINICAL CASE) An 11 year old male refractory iron deficiency anemia, fecal calprotectin at 1375 µg/g, video capsule endoscopy showed discrete linear serpiginous ulcers surrounding erythema duodenum proximal jejunum. Biopsy colon multiple granulomas terminal ileum entire suggesting CD (Inflammatory phenotype). Exclusive Enteral Nutrition (EEN) polymeric formula proved unsustainable. To nourish its ecosystem (Gastrosyn) that has blend HMO complimentary probiotic strains Lactobacilli Bifidobacterium was administered followed 20 weeks. Formulation also contained powerful antioxidant synergistic effect reducing inflammation. RESULTS After 4 weeks synbiotic, dropped 665ug/g further 110 ug/g by week 12. Complete deep remission observed 15 analyzed endoscopy/colonoscopy (images), histology lab tests results repeated several times (Calprotectin 65ug/g 15). Anemia significantly, patient continued tolerate solid foods no relapse even after 1year. CONCLUSIONS Synbiotics utilizing are used successful engraftment biome established recent literature. based Synbiotic proven nurture ecosystem, foster interactions, cross feeding, generation (SCFAs), providing IBD.